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MATERIALS AND METHODS
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RESULTS
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, Margaux Pontailler Department of Pediatric Cardiac Surgery, Necker Sick Children Hospital-M3C, University Paris Descartes, Paris, France Search for other works by this author on: Oxford Academic Moussa Haidar Department of Pediatric Cardiac Surgery, Necker Sick Children Hospital-M3C, University Paris Descartes, Paris, France Search for other works by this author on: Oxford Academic Mathilde Méot Department of Pediatric Cardiology, Necker Sick Children Hospital-M3C, University Paris Descartes, Paris, France Search for other works by this author on: Oxford Academic Anne Moreau de Bellaing Department of Pediatric Cardiology, Necker Sick Children Hospital-M3C, University Paris Descartes, Paris, France Search for other works by this author on: Oxford Academic Régis Gaudin Department of Pediatric Cardiac Surgery, Necker Sick Children Hospital-M3C, University Paris Descartes, Paris, France Search for other works by this author on: Oxford Academic Lucile Houyel Department of Pediatric Cardiology, Necker Sick Children Hospital-M3C, University Paris Descartes, Paris, France Search for other works by this author on: Oxford Academic Olivier Metton Cardio-Pediatric and Congenital Medico-Surgical Department C, Cardiologic Hospital Louis Pradel, Lyon, France Search for other works by this author on: Oxford Academic Pamela Moceri Department of Cardiology, Hôpital Pasteur, CHU de Nice, Nice, France Search for other works by this author on: Oxford Academic Damien Bonnet Department of Pediatric Cardiology, Necker Sick Children Hospital-M3C, University Paris Descartes, Paris, France Search for other works by this author on: Oxford Academic Pascal Vouhé Department of Pediatric Cardiac Surgery, Necker Sick Children Hospital-M3C, University Paris Descartes, Paris, France Search for other works by this author on: Oxford Academic
Olivier Raisky Department of Pediatric Cardiac Surgery, Necker Sick Children Hospital-M3C, University Paris Descartes, Paris, France Corresponding author. Department of Pediatric Cardiac Surgery, Necker Sick Children Hospital and Paris Descartes University, 149 rue de Sèvres, 75015 Paris, France. Tel: +33-1-44381864; fax: +33-1-44381863; e-mail: olivier.raisky@aphp.fr (O. Raisky). Search for other works by this author on: Oxford Academic
European Journal of Cardio-Thoracic Surgery, Volume 56, Issue 3, September 2019, Pages 541–548, https://doi.org/10.1093/ejcts/ezz085
Published:
20 March 2019
Article history
Received:
17 September 2018
Revision received:
13 January 2019
Accepted:
30 January 2019
Published:
20 March 2019
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Margaux Pontailler, Moussa Haidar, Mathilde Méot, Anne Moreau de Bellaing, Régis Gaudin, Lucile Houyel, Olivier Metton, Pamela Moceri, Damien Bonnet, Pascal Vouhé, Olivier Raisky, Double orifice and atrioventricular septal defect: dealing with the zone of apposition, European Journal of Cardio-Thoracic Surgery, Volume 56, Issue 3, September 2019, Pages 541–548, https://doi.org/10.1093/ejcts/ezz085
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Abstract
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OBJECTIVES
A double orifice of the left atrioventricular valve (LAVV) associated with atrioventricular septal defects (AVSD) can significantly complicate surgical repair. This study reports our experience of AVSD repair over 3 decades, with special attention to the zone of apposition (ZoA) of the main orifice, and presents a technique of hemivalve pericardial extension in specific situations.
METHODS
We performed a retrospective study from 1987 to 2016 on 1067 patients with AVSD of whom 43 (4%) had a double orifice, plus 2 additional patients who required LAVV pericardial enlargement. Median age at repair was 1.3 years. Mean follow-up was 8.2 years (1 month–32 years).
RESULTS
Associated abnormalities of the LAVV subvalvular apparatus were found in 7 patients (5 parachute LAVV and 2 absence of LAVV subvalvular apparatus). ZoA was noted in 4 patients (9%): partially closed in 15 (35%) and completely closed in 24 (56%). Four patients required, either at first repair or secondarily, a hemivalve enlargement using a pericardial patch without closure of the ZoA. The early mortality rate was 7% (n = 3), all before 2000. Two patients had unbalanced ventricles and the third had a single papillary muscle. There were no late deaths. Six patients (14%) required 7 reoperations (3 early and 4 late reoperations) for LAVV regurgitation and/or dysfunction, of whom 4 (9%) required mechanical LAVV replacement (all before 2000). Freedom from late LAVV reoperation was 97% at 1 year, 94% at 5 years and 87% at 10, 20 and 30 years. Unbalanced ventricles (P = 0.045), subvalvular abnormalities (P = 0.0037) and grade >2 LAVV postoperative regurgitation (P = 0.017) were identified as risk factors for LAVV reoperations. Freedom from LAVV mechanical valve replacement was 95% at 1 year, 90% at 5 years and 85% at 10, 20 and 30 years. An anomalous LAVV subvalvular apparatus was identified as a risk factor for mechanical valve replacement (P = 0.010). None of the patients who underwent LAVV pericardial extension had significant LAVV regurgitation at the last follow-up examination.
CONCLUSIONS
Repair of AVSD and double orifice can be tricky. Preoperative LAVV regurgitation was not identified as an independent predictor of surgical outcome. LAVV hemivalve extension appears to be a useful and effective alternate surgical strategy when the ZoA cannot be closed.
Atrioventricular septal defects, Atrioventricular canal defects, Double orifice, Mitral valve repair, Mitral valve replacement, Surgical technique, Outcomes, Congenital heart disease
INTRODUCTION
A double orifice (DO) of the left atrioventricular valve (LAVV) is a rare valvular cardiac abnormality that can be encountered in patients with congenital heart disease. A DO is rarely isolated but is usually associated with atrioventricular septal defects (AVSD), occasionally in association with obstructive left-sided lesions, cyanotic congenital heart disease and non-compaction of the left ventricle [1].
The incidence of DO LAVV has been reported in the literature to be around 3.6–7.5% [2–6].
DO LAVV in AVSD can significantly complicate surgical repair. Closure of the zone of apposition (ZoA) usually limits regurgitation (if the left mural valve of the orifice is correctly developed) but can create LAVV stenosis. Presence of a DO LAVV in AVSD has a bad reputation, leaving the patient at risk for LAVV dysfunction, reoperation and death [6–11].
This study reports our experience of AVSD repair over 3 decades, with or without closure of the ZoA, and presents a technique of hemivalve pericardial extension.
MATERIALS AND METHODS
Patient characteristics
From 1987 to 2016, 1067 patients with AVSD underwent surgical biventricular repair in our institution. Among them, 43 patients (4%) had a DO LAVV. We excluded patients who presented with AVSD and tetralogy of Fallot and patients who had severe unbalanced ventricles leading to univentricular repair. Patients with unbalanced ventricles but who underwent biventricular repair were included.
Two patients with AVSD and DO LAVV who were operated on by our surgical team in another institution and who required anterior hemivalve pericardial extension (need for extension was suspected from preoperative echocardiogram) were also included in this study (but not in the cohort data or statistical analysis) to report our experience with this surgical alternative.
DO anatomy and position were clearly documented in all patients but 1 (Table1): the DO was most frequently described as posterior in 31 patients (72%). Abnormalities of the left subvalvular apparatus were described in 7 patients, most frequently a parachute LAVV (5 patients).
Table 1:
Anatomy and fate of direct orifice left atrioventricular valve
LAVV anatomy and fate | N (%) |
---|---|
DO anatomy (data missing from 1 patient) | |
Posterior | 31 (72) |
Superior | 7 (16) |
Inferior | 3 (7) |
Septal | 1 (2) |
LAVV subvalvular apparatus abnormalities | |
Absence | 2 (5) |
Parachute LAVV | 5 (12) |
ZoA closure | |
Complete | 24 (56) |
Partial | 15 (35) |
None | 4 (9) |
LAVV MVR | 4 (9) |
LAVV anatomy and fate | N (%) |
---|---|
DO anatomy (data missing from 1 patient) | |
Posterior | 31 (72) |
Superior | 7 (16) |
Inferior | 3 (7) |
Septal | 1 (2) |
LAVV subvalvular apparatus abnormalities | |
Absence | 2 (5) |
Parachute LAVV | 5 (12) |
ZoA closure | |
Complete | 24 (56) |
Partial | 15 (35) |
None | 4 (9) |
LAVV MVR | 4 (9) |
DO: double orifice; LAVV: left atrioventricular valve; MVR: mechanical valve replacement; ZoA: zone of apposition.
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Table 1:
Anatomy and fate of direct orifice left atrioventricular valve
LAVV anatomy and fate | N (%) |
---|---|
DO anatomy (data missing from 1 patient) | |
Posterior | 31 (72) |
Superior | 7 (16) |
Inferior | 3 (7) |
Septal | 1 (2) |
LAVV subvalvular apparatus abnormalities | |
Absence | 2 (5) |
Parachute LAVV | 5 (12) |
ZoA closure | |
Complete | 24 (56) |
Partial | 15 (35) |
None | 4 (9) |
LAVV MVR | 4 (9) |
LAVV anatomy and fate | N (%) |
---|---|
DO anatomy (data missing from 1 patient) | |
Posterior | 31 (72) |
Superior | 7 (16) |
Inferior | 3 (7) |
Septal | 1 (2) |
LAVV subvalvular apparatus abnormalities | |
Absence | 2 (5) |
Parachute LAVV | 5 (12) |
ZoA closure | |
Complete | 24 (56) |
Partial | 15 (35) |
None | 4 (9) |
LAVV MVR | 4 (9) |
DO: double orifice; LAVV: left atrioventricular valve; MVR: mechanical valve replacement; ZoA: zone of apposition.
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Patients were divided in 2 groups, depending on the surgical ZoA operative strategy: either completely closed (n = 24/43) or respected (n = 19/43, no or partial closure).
Surgical management
Surgical technique for repair of atrioventricular septal defects
Surgical repair of AVSD was performed via a median sternotomy, with standard aortic and bicaval venous cannulation and normothermic cardiopulmonary bypass (35–37°C). Cardioplegia was obtained by infusion of anterograde normothermic hyperkalaemic blood in the aortic root and subsequently repeated every 10 min or less when myocardial activity resumed.
Diagnosis of DO LAVV was made with preoperative transthoracic echocardiography and/or identified at surgery. Closure of the ZoA was performed when the residual orifices were operatively evaluated as non-restrictive; otherwise, ZoA was partially closed or left open. None of the accessory DO were surgically closed; all of them were conserved because none was found to be significantly regurgitant at preoperative evaluation. If both VSD and ASD required closure, the double patch technique was used, preferentially with a heterologous pericardial patch. An LAVV commissuroplasty was performed in 11 patients.
The median age and weight at operation were 1.3 years (range 1 month–30 years) and 9 kg (range 3.2–50 kg), respectively.
Hemivalve pericardial patch enlargement
Four patients, 2 of our cohort and 2 patients operated on by our surgical team at another institution, required an anterior hemivalve pericardial patch enlargement (Fig.1). These patients presented with a specific anatomical configuration whereby complete closure of the ZoA was mandatory to obtain acceptable competence but would have been responsible for a significant degree of stenosis. In 2 cases, despite complete closure of the ZoA, residual regurgitation was significant (hypoplasia of the mural leaflet was related to the main orifice).
Figure 1:
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Enlargement of an anterior pericardial patch hemivalve. (A) Double-orifice left atrioventricular valve before repair: (1) ventricular crest; (2) accessory orifice; (3) line of incision for pericardial extension; (4) posteroinferior bridging leaflet; (5) anterosuperior bridging leaflet; (6) anterosuperior commissure; and (7) posteroinferior commissure). (B) The anterior bridging leaflet is detached and the treated autologous pericardial patch is sutured to increase leaflet coaptation; the zone of apposition and the double orifice are left open: (8) interatrial patch; (9) autologous pericardial patch extension; and (10) zone of coaptation.
An autologous pericardial patch was then harvested and treated in glutaraldehyde for 8–10 min. The hemivalve enlargement technique consisted of detaching the anterior bridging leaflet, 1 mm from the annulus and from the ZoA to the commissure. This technique can be applied to the posterior hemivalve. We do not divide the papillary muscle, even localized in the axis of the inflow, in order to avoid any prolapse. With this technique, the stenosis is not an issue because of the absence of complete closure of the ZoA. An oval autologous treated patch is sewn using 6/0 or 7/0 polypropylene running sutures, depending on the age of the patient at repair and the thickness of the leaflet. The ZoA is left totally or partially open to avoid tension and tearing. The increased hemivalve surface allows better LAVV coaptation. If deemed necessary, a commissuroplasty was performed to increase leaflet coaptation, only if a stenosis was not to be feared.
Data collection and follow-up
For this retrospective monocentric study, we reviewed our Paediatric Cardiac Surgery database to identify the patients who required biventricular repair for AVSD. The Paris V University Ethics Committee granted approval for review of health records. The need for individual consent was waived due to the retrospective nature of the study.
The mean follow-up was 8.2 years (1 month–32 years). The surviving patients had an annual examination by their referring cardiologist.
Statistical analysis
Continuous data are expressed as median and interquartile range or mean and standard deviation. Categorical data are expressed as number and percentage. Univariable analysis was performed using either the χ2 or the Fisher’s exact test for categorical data when cell frequencies were ≤5 or the Student's t-test for continuous data. A P-value <0.05 was considered significant. Overall survival and freedom from events were calculated using the Kaplan–Meier method with curves compared using the log-rank test. Data were analysed using GraphPad Prism version 6 software (GraphPad Software, La Jolla, CA, USA).
Although we report our experience in 45 patients, statistical analyses were performed only on the 43 patients who underwent initial repair in our institution.
RESULTS
Operative and postoperative data
Patient pre-, peri- and postoperative data are presented in Table2. The sex ratio was 1/2 (men/women).
Table 2:
Patient demographics
ZoA complete closure (n = 24) | ZoA conserved (partial closure or left open) (n = 19) | P value | |
---|---|---|---|
Preoperative data | |||
Male gender | 8 (33) | 6 (32) | 1 |
Age (years) | 1.7 (3.8) | 0.8 (4.2) | 0.53 |
Weight (kg) | 9.1 (8) | 8.3 (13) | 0.92 |
Year <2000 | 5 (21) | 8 (42) | 0.19 |
AVSD type | 0.76 | ||
cAVSD | 10 (42) | 10 (53) | |
iAVSD | 2 (8) | 1 (5) | |
pAVSD | 12 (50) | 8 (42) | |
Unbalanced ventricles | 1 (4) | 6 (32) | 0.032 |
Previous PAB | 0 | 2 (11) | 0.19 |
Peri- and postoperative data | |||
Preoperative LAVV regurgitation grade >2 | 4 (17) | 4 (21) | 1 |
CPB | 97 (40) | 108 (96) | 0.22 |
Aortic clamping | 62 (27) | 79 (72) | 0.085 |
Postoperative LAVV regurgitation grade >2 | 2 (8) | 0 | 0.49 |
Inotropic support (days) | 2 (4) | 1 (3) | 0.85 |
Ventilation time (h) | 10 (44) | 8 (39) | 0.14 |
ICU (days) | 3 (5) | 2 (5) | 0.40 |
Hospital stay (days) | 8 (4) | 7 (6) | 0.52 |
Outcomes | |||
Deaths | 1 (4) | 2 (11) | 0.58 |
Reoperation LAVV | 3 (12) | 3 (16) | 1 |
LAVV MVR | 2 (8) | 2 (11) | 1 |
Pericardial enlargement | 1 (4) | 1 (5) | 1 |
Pacemaker for AV block | 1 (4) | 0 | 1 |
ZoA complete closure (n = 24) | ZoA conserved (partial closure or left open) (n = 19) | P value | |
---|---|---|---|
Preoperative data | |||
Male gender | 8 (33) | 6 (32) | 1 |
Age (years) | 1.7 (3.8) | 0.8 (4.2) | 0.53 |
Weight (kg) | 9.1 (8) | 8.3 (13) | 0.92 |
Year <2000 | 5 (21) | 8 (42) | 0.19 |
AVSD type | 0.76 | ||
cAVSD | 10 (42) | 10 (53) | |
iAVSD | 2 (8) | 1 (5) | |
pAVSD | 12 (50) | 8 (42) | |
Unbalanced ventricles | 1 (4) | 6 (32) | 0.032 |
Previous PAB | 0 | 2 (11) | 0.19 |
Peri- and postoperative data | |||
Preoperative LAVV regurgitation grade >2 | 4 (17) | 4 (21) | 1 |
CPB | 97 (40) | 108 (96) | 0.22 |
Aortic clamping | 62 (27) | 79 (72) | 0.085 |
Postoperative LAVV regurgitation grade >2 | 2 (8) | 0 | 0.49 |
Inotropic support (days) | 2 (4) | 1 (3) | 0.85 |
Ventilation time (h) | 10 (44) | 8 (39) | 0.14 |
ICU (days) | 3 (5) | 2 (5) | 0.40 |
Hospital stay (days) | 8 (4) | 7 (6) | 0.52 |
Outcomes | |||
Deaths | 1 (4) | 2 (11) | 0.58 |
Reoperation LAVV | 3 (12) | 3 (16) | 1 |
LAVV MVR | 2 (8) | 2 (11) | 1 |
Pericardial enlargement | 1 (4) | 1 (5) | 1 |
Pacemaker for AV block | 1 (4) | 0 | 1 |
Categorical values are expressed as n (%) and quantitative values are expressed as median (interquartile range).
AV: atrioventricular; AVSD: atrioventricular septal defect; cAVSD: complete AVSD; CPB: cardiopulmonary bypass; iAVSD: intermediate AVSD; ICU: intensive care unit; LAVV: left atrioventricular valve; MVR: mechanical valve replacement; PAB: pulmonary artery banding; pAVSD: partial AVSD; ZoA: zone of apposition.
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Table 2:
Patient demographics
ZoA complete closure (n = 24) | ZoA conserved (partial closure or left open) (n = 19) | P value | |
---|---|---|---|
Preoperative data | |||
Male gender | 8 (33) | 6 (32) | 1 |
Age (years) | 1.7 (3.8) | 0.8 (4.2) | 0.53 |
Weight (kg) | 9.1 (8) | 8.3 (13) | 0.92 |
Year <2000 | 5 (21) | 8 (42) | 0.19 |
AVSD type | 0.76 | ||
cAVSD | 10 (42) | 10 (53) | |
iAVSD | 2 (8) | 1 (5) | |
pAVSD | 12 (50) | 8 (42) | |
Unbalanced ventricles | 1 (4) | 6 (32) | 0.032 |
Previous PAB | 0 | 2 (11) | 0.19 |
Peri- and postoperative data | |||
Preoperative LAVV regurgitation grade >2 | 4 (17) | 4 (21) | 1 |
CPB | 97 (40) | 108 (96) | 0.22 |
Aortic clamping | 62 (27) | 79 (72) | 0.085 |
Postoperative LAVV regurgitation grade >2 | 2 (8) | 0 | 0.49 |
Inotropic support (days) | 2 (4) | 1 (3) | 0.85 |
Ventilation time (h) | 10 (44) | 8 (39) | 0.14 |
ICU (days) | 3 (5) | 2 (5) | 0.40 |
Hospital stay (days) | 8 (4) | 7 (6) | 0.52 |
Outcomes | |||
Deaths | 1 (4) | 2 (11) | 0.58 |
Reoperation LAVV | 3 (12) | 3 (16) | 1 |
LAVV MVR | 2 (8) | 2 (11) | 1 |
Pericardial enlargement | 1 (4) | 1 (5) | 1 |
Pacemaker for AV block | 1 (4) | 0 | 1 |
ZoA complete closure (n = 24) | ZoA conserved (partial closure or left open) (n = 19) | P value | |
---|---|---|---|
Preoperative data | |||
Male gender | 8 (33) | 6 (32) | 1 |
Age (years) | 1.7 (3.8) | 0.8 (4.2) | 0.53 |
Weight (kg) | 9.1 (8) | 8.3 (13) | 0.92 |
Year <2000 | 5 (21) | 8 (42) | 0.19 |
AVSD type | 0.76 | ||
cAVSD | 10 (42) | 10 (53) | |
iAVSD | 2 (8) | 1 (5) | |
pAVSD | 12 (50) | 8 (42) | |
Unbalanced ventricles | 1 (4) | 6 (32) | 0.032 |
Previous PAB | 0 | 2 (11) | 0.19 |
Peri- and postoperative data | |||
Preoperative LAVV regurgitation grade >2 | 4 (17) | 4 (21) | 1 |
CPB | 97 (40) | 108 (96) | 0.22 |
Aortic clamping | 62 (27) | 79 (72) | 0.085 |
Postoperative LAVV regurgitation grade >2 | 2 (8) | 0 | 0.49 |
Inotropic support (days) | 2 (4) | 1 (3) | 0.85 |
Ventilation time (h) | 10 (44) | 8 (39) | 0.14 |
ICU (days) | 3 (5) | 2 (5) | 0.40 |
Hospital stay (days) | 8 (4) | 7 (6) | 0.52 |
Outcomes | |||
Deaths | 1 (4) | 2 (11) | 0.58 |
Reoperation LAVV | 3 (12) | 3 (16) | 1 |
LAVV MVR | 2 (8) | 2 (11) | 1 |
Pericardial enlargement | 1 (4) | 1 (5) | 1 |
Pacemaker for AV block | 1 (4) | 0 | 1 |
Categorical values are expressed as n (%) and quantitative values are expressed as median (interquartile range).
AV: atrioventricular; AVSD: atrioventricular septal defect; cAVSD: complete AVSD; CPB: cardiopulmonary bypass; iAVSD: intermediate AVSD; ICU: intensive care unit; LAVV: left atrioventricular valve; MVR: mechanical valve replacement; PAB: pulmonary artery banding; pAVSD: partial AVSD; ZoA: zone of apposition.
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AVSD was associated with Down syndrome in 6 (14%) patients. Major associated cardiac lesions included coarctation in 4 (9%) patients and a left partial anomalous pulmonary venous return in 1 patient (2%). Seven patients had unbalanced ventricles: mild to moderate hypoplasia of the left ventricle in all, 2 with associated coarctation of the aorta. Two patients (5%) required previous palliation with pulmonary artery banding.
Thirteen patients (30%) were operated on before 2000.
Preoperative LAVV regurgitation was described as none to trivial in 10 (23%) patients, grade 1 in 13 (30%) patients, grade 2 in 12 patients (28%), grade 3 in 4 patients (9%) and grade 4 in 4 patients (9%). Twenty-four patients (56%) underwent complete closure of the ZoA, whereas 15 (35%) had a partial closure. ZoA was left open in 4 patients (9%). All DO were surgically conserved because none were found to be significantly regurgitant at evaluation.
Postoperative LAVV regurgitation was none to trivial in 35 patients (81%), grade 2 in 6 (14%) and grade 4 in 2 (5%). Both patients with grade 4 postoperative LAVV regurgitation underwent subsequent early reoperation.
The ZoA tended to be more frequently only partially closed or left open in patients with unbalanced ventricles (P = 0.032) and who had required previous palliation by pulmonary artery banding (not significant) (Table2).
Mortality rate
The early mortality rate was 7% (n = 3), all before 2000. There were no late deaths (Fig.2A).
Figure 2:
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Survival and freedom from reoperation after surgical repair of atrioventricular septal defect with direct orifice left atrioventricular valve. (A) Overall survival was 95% [95% confidence interval (CI): 92–100] at 30 days and 93% (95% CI: 88–100) at 1, 5, 10, 20 and 30 years. (B) Freedom from left atrioventricular valve reoperation was 93% (95% CI: 87–100) at 30 days, 90% (95% CI: 83–100) at 1 year, 87% (95% CI: 79–100) at 5 years and 80% (95% CI: 70–100) at 10, 20 and 30 years. (C) Freedom from late left atrioventricular valve reoperation was 97% at 1 year (95% CI: 95–100), 94% at 5 years (95% CI: 90–100) and 87% (95% CI: 79–100) at 10, 20 and 30 years. (D) Freedom from LAVV MVR was 95% at 1 year (95% CI: 90–100), 90% at 5 years (95% CI: 86–100) and 85% (95% CI: 75–100) at 10, 20 and 30 years. LAVV: left atrioventricular valve; MVR: mechanical valve replacement.
The first patient had a partial AVSD with balanced ventricles and a single papillary muscle associated with the DO LAVV. The ZoA had been completely closed during repair but postoperative echocardiography showed grade 4 LAVV regurgitation. He underwent LAVV mechanical valve replacement (MVR) after a second LAVV repair failed, 12 days after the initial repair, but he did not survive.
The other 2 patients had unbalanced ventricles (left ventricular end-diastolic volume: z score −4 DS) and the ZoA had only been partially closed. The first patient had been diagnosed with complete AVSD and grade 4 preoperative LAVV regurgitation. He died the night after surgery of pulmonary oedema and biventricular dysfunction. Necropsy found a stenotic LAVV. The second patient had a post-natal diagnosis of partial AVSD associated with aortic coarctation. He underwent ostium primum closure, partial ZoA closure and coarctation repair when he was 1 month old. He died 75 days after repair of septic shock complicating a chylothorax that had required thoracic duct ligation. At the last echocardiogram, the mean LAVV gradient was 2 mmHg, associated with grade 2 LAVV regurgitation.
Table3 summarizes the univariable analysis of risk factors for mortality. Surgery before 2000 was identified as a risk factor for mortality (P = 0.045). Early MVR and presence of unbalanced ventricles showed a trend but no statistical significance was found (P-value: 0.070 and 0.064, respectively).
Table 3:
Univariable analysis of risk factors for mortality in patients with atrioventricular septal defect and direct orifice left atrioventricular valve
Risks factors for death | P-value |
---|---|
Preoperative factors | |
AVSD type | 1.0 |
Down syndrome | 1.0 |
Preoperative LAVV regurgitation grade >2 | 0.47 |
Unbalanced ventricles | 0.064 |
Subvalvular apparatus abnormalities | 0.064 |
Perioperative factors | |
Surgery before 2000 | 0.045 |
ZoA closure | 0.58 |
Postoperative factors | |
Postoperative LAVV regurgitation grade >2 | 0.14 |
Early MVR | 0.07 |
Risks factors for death | P-value |
---|---|
Preoperative factors | |
AVSD type | 1.0 |
Down syndrome | 1.0 |
Preoperative LAVV regurgitation grade >2 | 0.47 |
Unbalanced ventricles | 0.064 |
Subvalvular apparatus abnormalities | 0.064 |
Perioperative factors | |
Surgery before 2000 | 0.045 |
ZoA closure | 0.58 |
Postoperative factors | |
Postoperative LAVV regurgitation grade >2 | 0.14 |
Early MVR | 0.07 |
Only surgery before 2000 was statistically significant. Unbalanced ventricles, subvalvular abnormalities and early MVR showed a trend but no statistical significance was reported.
AVSD: atrioventricular septal defect; LAVV: left atrioventricular valve; MVR: mechanical valve replacement; ZoA: zone of apposition.
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Table 3:
Univariable analysis of risk factors for mortality in patients with atrioventricular septal defect and direct orifice left atrioventricular valve
Risks factors for death | P-value |
---|---|
Preoperative factors | |
AVSD type | 1.0 |
Down syndrome | 1.0 |
Preoperative LAVV regurgitation grade >2 | 0.47 |
Unbalanced ventricles | 0.064 |
Subvalvular apparatus abnormalities | 0.064 |
Perioperative factors | |
Surgery before 2000 | 0.045 |
ZoA closure | 0.58 |
Postoperative factors | |
Postoperative LAVV regurgitation grade >2 | 0.14 |
Early MVR | 0.07 |
Risks factors for death | P-value |
---|---|
Preoperative factors | |
AVSD type | 1.0 |
Down syndrome | 1.0 |
Preoperative LAVV regurgitation grade >2 | 0.47 |
Unbalanced ventricles | 0.064 |
Subvalvular apparatus abnormalities | 0.064 |
Perioperative factors | |
Surgery before 2000 | 0.045 |
ZoA closure | 0.58 |
Postoperative factors | |
Postoperative LAVV regurgitation grade >2 | 0.14 |
Early MVR | 0.07 |
Only surgery before 2000 was statistically significant. Unbalanced ventricles, subvalvular abnormalities and early MVR showed a trend but no statistical significance was reported.
AVSD: atrioventricular septal defect; LAVV: left atrioventricular valve; MVR: mechanical valve replacement; ZoA: zone of apposition.
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There was no statistically significant difference regarding the preoperative and postoperative LAVV regurgitation (P-value: 0.47 and 0.14, respectively) or the ZoA surgical strategy (P = 0.58).
Reoperations
Nine patients (21%) required subsequent reoperation after surgical repair: 6 for LAVV dysfunction, 1 pacemaker implantation for complete AV block, 1 for pericardial effusion and 1 for subaortic resection 12 years after the initial surgery.
Six patients (14%) required 7 reinterventions on the LAVV. Three patients required early reintervention at 3, 12 and 14 days after surgery. Two patients underwent subsequent LAVV repair (1 with an anterior hemivalve pericardial enlargement), whereas the third patient required LAVV MVR because the re-repair failed, leading to death. Three patients from the initial cohort required late reoperation consisting of LAVV MVR in all cases, 5 months, 2 years and 7 years, respectively, after the initial repair. All 3 patients are doing well at a median interval of 13 years after the initial surgery (5–15 years).
Unbalanced ventricles (P = 0.045), subvalvular abnormalities (P = 0.0037) and grade >2 LAVV postoperative regurgitation (P = 0.017) were identified as risk factors for LAVV reoperations in patients with DO LAVV (Table4).
Table 4:
Univariable analysis of risk factors for left atrioventricular valve reoperation in patients with atrioventricular septal defect and direct orifice left atrioventricular valve
Risks factors for LAVV reoperation | P-value |
---|---|
Preoperative factors | |
AVSD type | 1.0 |
Down syndrome | 1.0 |
Preoperative LAVV regurgitation grade >2 | 1.0 |
Unbalanced ventricles | 0.045 |
Subvalvular apparatus abnormalities | 0.004 |
Perioperative factors | |
Surgery before 2000 | 1.0 |
ZoA closure | 1.0 |
Postoperative factors | |
Postoperative LAVV regurgitation grade >2 | 0.017 |
Risks factors for LAVV reoperation | P-value |
---|---|
Preoperative factors | |
AVSD type | 1.0 |
Down syndrome | 1.0 |
Preoperative LAVV regurgitation grade >2 | 1.0 |
Unbalanced ventricles | 0.045 |
Subvalvular apparatus abnormalities | 0.004 |
Perioperative factors | |
Surgery before 2000 | 1.0 |
ZoA closure | 1.0 |
Postoperative factors | |
Postoperative LAVV regurgitation grade >2 | 0.017 |
Unbalanced ventricles, subvalvular abnormalities and postoperative regurgitation were identified as risk factors for LAVV reoperations.
AVSD: atrioventricular septal defect; LAVV: left atrioventricular valve; ZoA: zone of apposition.
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Table 4:
Univariable analysis of risk factors for left atrioventricular valve reoperation in patients with atrioventricular septal defect and direct orifice left atrioventricular valve
Risks factors for LAVV reoperation | P-value |
---|---|
Preoperative factors | |
AVSD type | 1.0 |
Down syndrome | 1.0 |
Preoperative LAVV regurgitation grade >2 | 1.0 |
Unbalanced ventricles | 0.045 |
Subvalvular apparatus abnormalities | 0.004 |
Perioperative factors | |
Surgery before 2000 | 1.0 |
ZoA closure | 1.0 |
Postoperative factors | |
Postoperative LAVV regurgitation grade >2 | 0.017 |
Risks factors for LAVV reoperation | P-value |
---|---|
Preoperative factors | |
AVSD type | 1.0 |
Down syndrome | 1.0 |
Preoperative LAVV regurgitation grade >2 | 1.0 |
Unbalanced ventricles | 0.045 |
Subvalvular apparatus abnormalities | 0.004 |
Perioperative factors | |
Surgery before 2000 | 1.0 |
ZoA closure | 1.0 |
Postoperative factors | |
Postoperative LAVV regurgitation grade >2 | 0.017 |
Unbalanced ventricles, subvalvular abnormalities and postoperative regurgitation were identified as risk factors for LAVV reoperations.
AVSD: atrioventricular septal defect; LAVV: left atrioventricular valve; ZoA: zone of apposition.
Open in new tab
Long-term overall freedom from LAVV reoperation, freedom from late LAVV reoperation and freedom from LAVV MVR were 80% [95% confidence interval (CI) 70–100], 87% (95% CI 79–100) and 85% (95% CI 75–100), respectively (Fig.2B–D).
Subvalvular abnormalities were identified as a risk factor for MVR (P = 0.010).
Anterior hemivalve pericardial enlargement
Four patients, 2 of our cohort and 2 patients operated on by our surgical team in another institution, required an anterior hemivalve pericardial patch enlargement. This technique was performed during the initial repair in 2 patients and when the LAVV reoperation was required in the other 2 patients (1 early reoperation 3 days after initial repair and 1 late repair 3 years after surgery). Patient characteristics are described in Table5. There were 3 partial AVSD and 1 intermediate AVSD. Two patients had a single papillary muscle.
Table 5:
Characteristics of patients who required hemivalve pericardial patch enlargement
Patient number | Diagnosis | Age at initial repair | Indication for patch enlargement | Preoperative LAVV regurgitation | Last follow-up results |
---|---|---|---|---|---|
1 | pAVSD; posterior DO; single papillary muscle | 1.2 years |
| Grade 2 (initial repair)/grade 4 (reoperation) | At 7 years: grade 1 regurgitation; no LAVV stenosis; sports in elementary school |
2 | iAVSD; posterior DO | 4.5 years | Initial repair: left hemivalve patch enlargement; partial ZoA closure | Grade 3 | At 3 years: no regurgitation; mean gradient 2 mmHg |
3 | pAVSD; anterior DO | 9 months | Initial repair: left hemivalve patch enlargement; ZoA left open | Grade 1 | At 1 year: no regurgitation; mean gradient 2 mmHg |
4 | pAVSD; single papillary muscle | 1.1 years |
| No regurgitation (initial repair)/grade 4, no stenosis (reoperation) | At 1 year after reoperation: trivial LAVV regurgitation; mean gradient 7 mmHg |
Patient number | Diagnosis | Age at initial repair | Indication for patch enlargement | Preoperative LAVV regurgitation | Last follow-up results |
---|---|---|---|---|---|
1 | pAVSD; posterior DO; single papillary muscle | 1.2 years |
| Grade 2 (initial repair)/grade 4 (reoperation) | At 7 years: grade 1 regurgitation; no LAVV stenosis; sports in elementary school |
2 | iAVSD; posterior DO | 4.5 years | Initial repair: left hemivalve patch enlargement; partial ZoA closure | Grade 3 | At 3 years: no regurgitation; mean gradient 2 mmHg |
3 | pAVSD; anterior DO | 9 months | Initial repair: left hemivalve patch enlargement; ZoA left open | Grade 1 | At 1 year: no regurgitation; mean gradient 2 mmHg |
4 | pAVSD; single papillary muscle | 1.1 years |
| No regurgitation (initial repair)/grade 4, no stenosis (reoperation) | At 1 year after reoperation: trivial LAVV regurgitation; mean gradient 7 mmHg |
AVSD: atrioventricular septal defect; DO: double orifice; iAVSD: intermediate AVSD; LAVV: left atrioventricular valve; pAVSD: partial AVSD; ZoA: zone of apposition.
Open in new tab
Table 5:
Characteristics of patients who required hemivalve pericardial patch enlargement
Patient number | Diagnosis | Age at initial repair | Indication for patch enlargement | Preoperative LAVV regurgitation | Last follow-up results |
---|---|---|---|---|---|
1 | pAVSD; posterior DO; single papillary muscle | 1.2 years |
| Grade 2 (initial repair)/grade 4 (reoperation) | At 7 years: grade 1 regurgitation; no LAVV stenosis; sports in elementary school |
2 | iAVSD; posterior DO | 4.5 years | Initial repair: left hemivalve patch enlargement; partial ZoA closure | Grade 3 | At 3 years: no regurgitation; mean gradient 2 mmHg |
3 | pAVSD; anterior DO | 9 months | Initial repair: left hemivalve patch enlargement; ZoA left open | Grade 1 | At 1 year: no regurgitation; mean gradient 2 mmHg |
4 | pAVSD; single papillary muscle | 1.1 years |
| No regurgitation (initial repair)/grade 4, no stenosis (reoperation) | At 1 year after reoperation: trivial LAVV regurgitation; mean gradient 7 mmHg |
Patient number | Diagnosis | Age at initial repair | Indication for patch enlargement | Preoperative LAVV regurgitation | Last follow-up results |
---|---|---|---|---|---|
1 | pAVSD; posterior DO; single papillary muscle | 1.2 years |
| Grade 2 (initial repair)/grade 4 (reoperation) | At 7 years: grade 1 regurgitation; no LAVV stenosis; sports in elementary school |
2 | iAVSD; posterior DO | 4.5 years | Initial repair: left hemivalve patch enlargement; partial ZoA closure | Grade 3 | At 3 years: no regurgitation; mean gradient 2 mmHg |
3 | pAVSD; anterior DO | 9 months | Initial repair: left hemivalve patch enlargement; ZoA left open | Grade 1 | At 1 year: no regurgitation; mean gradient 2 mmHg |
4 | pAVSD; single papillary muscle | 1.1 years |
| No regurgitation (initial repair)/grade 4, no stenosis (reoperation) | At 1 year after reoperation: trivial LAVV regurgitation; mean gradient 7 mmHg |
AVSD: atrioventricular septal defect; DO: double orifice; iAVSD: intermediate AVSD; LAVV: left atrioventricular valve; pAVSD: partial AVSD; ZoA: zone of apposition.
Open in new tab
All operations were uneventful. Apart from the patient who underwent a reoperation 3 days after the initial repair and had to remain in the intensive care unit (ICU) for 5 days, the other 3 patients were weaned from mechanical ventilation and inotropic support in the first hours after surgery (h 2–h 4) and were discharged from the ICU the day after surgery with a mean hospital stay of 10 days.
At the last follow-up (1–7 years), all patients are doing well, with none-to-trivial LAVV regurgitation and no LAVV stenosis.
DISCUSSION
Atrioventricular septal defects and double-orifice left atrioventricular valve
Survival
The presence of a DO LAVV has often been incriminated as putting the patient at risk for LAVV dysfunction and reoperation after AVSD repair and even for death after reoperation [6–12]. Only a few publications describe the outcome of patients with AVSD with LAVV DO. Hoohenkerk et al. [4] reported their experience with 21 patients: no early deaths and 3 late deaths with an overall survival of 84% at 15 years. Although the mortality rate was high (14%), survival did not significantly differ between patients with AVSD with and without a DO-LAVV. Sharma et al. [5] had similar findings, with a 15-year survival rate of 86%. We report a higher survival rate, over 90% long-term. The overall mortality rate has dramatically dropped since 2000 and now appears to be close to that of standard AVSD without associated lesions. We are strongly convinced that the decrease in the mortality rate is directly correlated with the achievement of an optimal repair.
Management of the double orifice
The Mayo Clinic team suggested the following management for DO-LAVV: do not divide the tissue bridge; cleft closure must be achieved except when the valve area is small, the mural leaflet is dysplastic and/or a single papillary muscle is present; a competent DO must be conserved but closed with a patch if regurgitant; if the DO must be closed, the ZoA should not be completely closed [5]. We agree with these recommendations even though some details need to be clarified. Respect for the bridging tissue valve and ZoA closure are the 2 key determinants for an easy and effective repair. Nevertheless, ZoA closure can be problematic in specific situations. If the residual orifice is too small, organic stenosis can be encountered, especially when there is a single papillary muscle or an underdeveloped mural leaflet. It is always difficult to appreciate accurately the functional residual orifice, although we can estimate the inflow by adding the surface area of each orifice. Calibration of the residual orifice can lead to tears in the repair, and the functional orifice is also correlated with the anatomy of the subvalvular apparatus, which can create a restriction. We cannot say that, in our experience, none of the ZoA have been left open in the presence of a single papillary muscle or dysplastic mural leaflet, but clearly, it is a complex repair, and partial closure, no closure or primitive patch augmentation has to be considered.
Surgical management of the ZoA remains the challenge of the AVSD repair, because incomplete ZoA closure has been reported in previous publications to be associated with poor outcome, death and reoperations [6, 13, 14]. Association with abnormalities of the subvalvular apparatus, especially a single papillary muscle, can complicate surgical repair and make one reconsider the initially planned surgical management of the LAVV. In our series, abnormalities of the subvalvular apparatus have been identified as a risk factor for both LAVV reoperations and MVR. Definitively, transoesophageal echocardiography remains mandatory in this situation (accepted mean gradient up to 5 mmHg).
Reoperations for left atrioventricular valve dysfunction
Postoperative LAVV dysfunction is the main indication for AVSD reoperations [9, 15, 16]. Risk factors such as preoperative LAVV regurgitation, unbalanced ventricles, incomplete cleft closure, DO-LAVV and the absence of Down syndrome have been reported in the literature [4, 6, 7, 14, 17–20]. When reoperation is required, one should always try to re-repair the LAVV because MVR still remains associated with a worse outcome than valvuloplasty in patients with AVSD [6, 12, 21].
Freedom from LAVV reoperation in our cohort goes along with previously reported outcomes after AVSD and DO-LAVV repair [4, 5]. We also confirmed the bad reputations of postoperative LAVV regurgitation, unbalanced ventricles and subvalvular apparatus abnormalities. Although early MVR in 1 patient led to death, the other 3 patients who required late MVR are still alive after a median follow-up of 13 years. Evolution in surgical strategies, postoperative management of the patients with AVSD in the ICU and improvements in the supervision of anticoagulation therapy decreased the morbidity and mortality rates of paediatric patients with mechanical valves, but valve repair has to be the first choice and, most of the time, can be achieved in expert hands.
Pericardial patch enlargement as an alternate surgical strategy
Different surgical strategies can be used for LAVV re-repair in AVSD: complete cleft closure; cleft patch augmentation with bovine or pericardial patch or via the use of a mitral valve hom*ograft; leaflet augmentation technique; and Gore-Tex artificial chordae placement [22–24].
As described in this manuscript and by others, we initially used pericardial patch bridging leaflet extension in AVSD with DO LAVV in re-repair for residual regurgitation with an excellent early outcome. Secondly, this technique has been considered at the first repair when ZoA closure was ineffective (residual regurgitation or estimated low coaptation surface height) or obviously stenotic. These situations were particularly encountered in cases of subvalvular apparatus abnormalities, underdeveloped mural leaflet and, rarely, asymmetric bridging leaflets. We are strongly convinced that this technique can be helpful in patients in whom competence is difficult to achieve without stenosis. Because leaflet extension does not meet the surface of coaptation, we expect the repair to last and to avoid the adverse outcomes of partial or no closure.
CONCLUSION
Repair of AVSD and DO LAVV is every paediatric cardiac surgeon’s challenge. Preoperative LAVV regurgitation is not reliable for predicting results of surgery whereas significant postoperative LAVV regurgitation was identified as a risk factor for reoperation but not for survival, as were unbalanced ventricles and abnormalities of the subvalvular apparatus.
LAVV hemivalve pericardial extension appears to be a useful and effective alternate surgical strategy when leaflets and subvalvular apparatus appear to be deficient and the ZoA cannot be closed.
Conflict of interest: none declared.
† Presented at the 32nd Annual Meeting of the European Association for Cardio-Thoracic Surgery, Milan, Italy, 18–20 October 2018.
REFERENCES
1
Séguéla PE Houyel L Acar P.
Congenital malformations of the mitral valve
.
Arch Cardiovasc Dis
2011
;
104
:
465
–
79
.
2
Lee CN Danielson GK Schaff HV Puga FJ Mair DD.
Surgical treatment of double-orifice mitral valve in atrioventricular canal defects. Experience in 25 patients
.
J Thorac Cardiovasc Surg
1985
;
90
:
700
–
5
.
3
Al-Hay AA MacNeill SJ Yacoub M Shore DF Shinebourne EA.
Complete atrioventricular septal defect, Down syndrome, and surgical outcome: risk factors
.
Ann Thorac Surg
2003
;
75
:
412
–
21
.
4
Hoohenkerk GJ Wenink AC Schoof PH Koolbergen DR Bruggemans EF Rijlaarsdam M.
Results of surgical repair of atrioventricular septal defect with double-orifice left atrioventricular valve
.
J Thorac Cardiovasc Surg
2009
;
138
:
1167
–
71
.
5
Sharma V Burkhart HM Schaff HV Cabalka AK Grogan MA Dearani JA.
Double-orifice left atrioventricular valve in patients with atrioventricular septal defects: surgical strategies and outcome
.
Ann Thorac Surg
2012
;
93
:
2017
–
20
; discussion 2020–1.
6
Pontailler M Kalfa D Garcia E Ly M Le Bret E Roussin R
Reoperations for left atrioventricular valve dysfunction after repair of atrioventricular septal defect
.
Eur J Cardiothorac Surg
2014
;
45
:
557
; discussion 563.
7
Michielon G Stellin G Rizzoli G Milanesi O Rubino M Moreolo GS
Left atrioventricular valve incompetence after repair of common atrioventricular canal defects
.
Ann Thorac Surg
1995
;
60(Suppl. 6)
:
S604
–
9
.
8
Bando K Turrentine MW Sun K Sharp TG
Ensing
GJ
,Miller
AP
et al.Surgical management of complete atrioventricular septal defects. A twenty-year experience
.
J Thorac Cardiovasc Surg
1995
;
110
:
1543
–
52
; discussion 1552–4.
9
Najm HK Coles JG Endo M Stephens D Rebeyka IM Williams WG
Complete atrioventricular septal defects: results of repair, risk factors, and freedom from reoperation
.
Circulation
1997
;
96
:
II311
–
5
.
OpenURL Placeholder Text
10
Nakano T Kado H Shiokawa Y f*ckae K.
Surgical results of double-orifice left atrioventricular valve associated with atrioventricular septal defects
.
Ann Thorac Surg
2002
;
73
:
69
–
75
.
11
Ando M Takahashi Y.
Variations of atrioventricular septal defects predis-posing to regurgitation and stenosis
.
Ann Thorac Surg
2010
;
90
:
614
–
21
.
12
Sojak V Kooij M Yazdanbakhsh A Koolbergen DR Bruggemans EF Hazekamp MG.
A single-centre 37-year experience with reoperation after primary repair of atrioventricular septal defect
.
Eur J Cardiothorac Surg
2016
;
49
:
538
–
45
.
13
Wetter J Sinzobahamvya N Blaschczok C Brecher AM Grävinghoff LM Schmaltz AA
Closure of the zone of apposition at correction of complete atrioventricular septal defect improves outcome
.
Eur J Cardiothorac Surg
2000
;
17
:
146
–
53
.
14
Hoohenkerk GJ Bruggemans EF Rijlaarsdam M Schoof PH Koolbergen DR Hazekamp MG.
More than 30 years’ experience with surgical correction of atrioventricular septal defects
.
Ann Thorac Surg
2010
;
90
:
1554
–
61
.
15
Kaza AK Colan SD Jaggers J Lu M Atz AM Sleeper LA
Pediatric Heart Network Investigators. Surgical interventions for atrioventricular septal defect subtypes: the pediatric heart network experience
.
Ann Thorac Surg
2011
;
92
:
1468
–
75
; discussion 1475.
16
Najm HK Williams WG Chuaratanaphong S Watzka SB Coles JG Freedom RM.
Primum atrial septal defect in children: early results, risk factors, and freedom from reoperation
.
Ann Thorac Surg
1998
;
66
:
829
–
35
.
17
Baufreton C Journois D Leca F Khoury W Tamisier D Vouhé P.
Ten-year experience with surgical treatment of partial atrioventricular septal defect: risk factors in the early postoperative period
.
J Thorac Cardiovasc Surg
1996
;
112
:
14
–
20
.
18
Formigari R Di Donato RM Gargiulo G Di Carlo D Feltri C Picchio FM
Better surgical prognosis for patients with complete atrioventricular septal defect and Down’s syndrome
.
Ann Thorac Surg
2004
;
78
:
666
–
72
; discussion 672.
19
Ten Harkel AD Cromme-Dijkhuis AH Heinerman BC Hop WC Bogers AJ.
Development of left atrioventricular valve regurgitation after correction of atrioventricular septal defect
.
Ann Thorac Surg
2005
;
79
:
607
–
12
.
20
Lange R Guenther T Busch R Hess J Schreiber C.
The presence of Down syndrome is not a risk factor in complete atrioventricular septal defect repair
.
J Thorac Cardiovasc Surg
2007
;
134
:
304
–
10
.
21
Alsoufi B Al-Halees Z Khouqeer F Canver CC Siblini G Saad E
Results of left atrioventricular valve reoperations following previous repair of atrioventricular septal defects
.
J Card Surg
2010
;
25
:
74
–
8
.
22
Poirier NC Williams WG Van Arsdell GS Coles JG Smallhorn JF Omran A
A novel repair for patients with atrioventricular septal defect requiring reoperation for left atrioventricular valve regurgitation
.
Eur J Cardiothorac Surg
2000
;
18
:
54
–
61
.
23
Artrip JH Rumball EM Finucane K.
Repair of left atrioventricular valve cleft defects with patch augmentation
.
Ann Thorac Surg
2012
;
93
:
2081
–
3
.
24
Sughimoto K d'Udekem Y Konstantinov IE Brizard CP.
Mid-term outcome with pericardial patch augmentation for redo left atrioventricular valve repair in atrioventricular septal defect
.
Eur J Cardiothorac Surg
2016
;
49
:
157
–
66
.
© The Author(s) 2019. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Topic:
- pericardial sac
- mitral valve
- atrioventricular septal defect
- preoperative care
- repeat surgery
- surgical procedures, operative
- vomiting
- hypertrophy
- apposition
Issue Section:
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